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Individualized chemotherapy for veterinary cancer patients: New trick or old dog?

Individualized chemotherapy for veterinary cancer patients: New trick or old dog?

Individualized chemotherapy for veterinary cancer patients: New trick or old dog?

Veterinary Cancer Society
Veterinary Cancer Society
on behalf of Missouri Veterinary Medical Association

$FREE $ FREE $ FREE

$ FREE $ FREE $ FREE
$ 37.50 $ 37.50 $ 37.50
Normal Price: FREE $37.50

Review:

Launch date: 09 Feb 2017
Expiry Date:

Last updated: 10 Feb 2017

Reference: 168076

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Course Availability

This course is only available to trainees days after purchase. It would need to be repurchased by the trainee if not completed in the allotted time period. This course is no longer available. You will need to repurchase if you wish to take the course again.

Description

The modern concept of “personalized” chemotherapy involves the use of molecular and genetic analyses to identify driver mutations within individual patients’ tumors that may be targeted using drugs. While this approach has come of age within the past decade, the notion of specifically tailoring cancer drug treatments to fit the needs of an individual patient is not new – it has been standard practice for most medical oncologists long prior to the advent of molecularly targeted therapies. The first half of this review session will therefore cover principles of chemotherapy drug selection for individual cancer patients, specifically in the context of classical cytotoxic agents. This half will focus on drug, patient, and tumor factors that affect the efficacy and tolerability of cytotoxic drugs. The molecular pharmacology, toxicology, and mechanisms of resistance to select cytotoxic agents commonly used in small animal oncology practice will be reviewed. The second half of the review will focus on the use of molecularly targeted agents for personalized cancer chemotherapy. The molecular mechanisms underlying tumor response and resistance to targeted agents, in both veterinary and human cancer patients, will be discussed in detail. Historical notes on the development of targeted approaches to chemotherapy, and lessons learned from the shortcomings of these approaches, will be used to enrich this discussion. Finally, at the session’s conclusion, novel approaches to personalized chemotherapy using phenotypic profiling tools, such as patient-derived xenografts, will be discussed briefly.

Objectives

Learning Objectives:
• Understand the concept of therapeutic index and how it shapes cancer chemotherapy dosing practice. Understand how therapeutic index differs in the application of cytotoxic and targeted chemotherapy agents, and why this difference occurs.
• Understand major mechanisms of tumor resistance to cytotoxic and targeted chemotherapy agents and how drug resistance limits the effective use of these agents in the clinic.
• Understand the implications of genomic instability as a hallmark trait of cancer, and how this affects our ability to cure cancers using medical therapy.
Veterinary Cancer Society

Author Information Play Video Bio

Veterinary Cancer Society
on behalf of Missouri Veterinary Medical Association

Dr. Michael Childress - Michael Childress received his DVM degree from the Virginia-Maryland Regional College of Veterinary Medicine in 2004. He subsequently completed a rotating internship at Kansas State University and an internship in medical oncology at the University of Georgia, before coming to Purdue University, where he completed a residency and master’s degree in comparative oncology. He is currently an assistant professor of comparative oncology with the Purdue Department of Veterinary Clinical Sciences and chief of the medical oncology section at the Purdue University Veterinary Teaching Hospital.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

  • Missouri Veterinary Medical Association
  • 1.50 Hours -
    Exam Attempts: 3
    -
    Exam Pass Rate: 50

Faculty and Disclosures

Additional Contributors

Conflicts Declared

Conflicts of Interest declaration by Author:

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